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The new Code of Fundraising Practice came into effect in October 2019. The changes are designed to make it easier for fundraisers, charities and third-party organisations to understand the standards expected of them when fundraising.

https://www.fundraisingregulator.org.uk/code

Do you want to know more about oesophageal cancer and developments in treatment?

Come along to an information evening, hosted by Maggie’s Glasgow & The OPA

The evening will include a presentation by Consultant Surgeon, Grant Fullarton, followed by Hannah Smith reflecting on her personal experience – ‘Looking back sprinting forward – my story after oesophageal surgery’.

This session is available for anyone with a cancer diagnosis, family, friends & professionals.

When: Wednesday 26 October, 6-8pm
Where: Maggie’s Glasgow, Gartnavel hospital campus

If you wish to attend please call 0141 357 2269 or speak to a member of staff in Maggie’s Glasgow.

Download the meeting flyer

Find out more about Maggie’s Glasgow on our support page

Surgeons at St George’s carried out a new endoscopic treatment for acid reflux, called Stretta, for the first time in October.

This means that St George’s is now the only NHS hospital in the UK to offer a fully comprehensive endoscopic and surgical anti-reflux service.

Acid reflux, otherwise known as heartburn, is a chronic condition where stomach acid passes into the oesophagus causing a variety of symptoms including pain and regurgitation.

It affects approximately 20% of the population and although medication is usually successful in treating this condition, some patients with severe symptoms require surgery.

Traditionally this would involve major abdominal surgery, called fundoplication, which involves wrapping the stomach around the oesophagus. Although effective, it has a number of side effects which is why the St George’s upper gastrointestinal surgical team investigated new approaches to develop less invasive surgical treatments for reflux.

Over the last four years, the team at St George’s has successfully introduced Linx – a less invasive surgical operation involving the insertion of a magnetic barrier ring to improve acid reflux symptoms, before introducing the latest procedure Stretta.

Stretta involves the insertion of an endoscope via the mouth to strengthen the muscles around the bottom part of the oesophagus. This technique has the advantage of avoiding the need for surgical incisions and can even be done without the need for general anaesthesia.

Tony Garbutt, 70, was the first patient at St George’s to undergo Stretta under the care of Mr Marcus Reddy and Mr Omar Khan, Upper Gastrointestinal Surgeons.

He said: “My symptoms were getting so bad that I was having real difficulty in breathing. I couldn’t have invasive surgery that was previously available, so this new procedure really is life-changing for me.”

Tony, a builder from South Croydon, suffered with acid reflux symptoms for twenty years and took medication every day in an attempt to keep the symptoms at bay before being transferred to St George’s when Stretta became available.

He said: “I’m so thankful to the team at St George’s, everything went smoothly and I’m back to work and living symptom free!”

Mr Reddy, who led the procedure, said: “I’m delighted to have introduced Stretta to St George’s. It’s much better for our patients – like Tony – to avoid invasive surgery, and they can go home on the same day.

He added: “Although it’s not suitable for everyone, those who are able to have the procedure are those who have the most severe symptoms and will see a huge difference.”

Mr Khan said: “As a supra-regional specialist centre for reflux surgery, St George’s already attracts local and national referrals but the addition of Stretta, along with our existing Linx programme means we are now the only NHS hospital in the UK to be able to offer a fully comprehensive endoscopic and surgical anti-reflux service for our patients.

He added: “This reinforces our position as national leaders and innovators in benign upper gastrointestinal surgery.”

Mr Marcus Reddy and Mr Omar Khan also carried out the first gastric bypass operation as a day case at St George’s earlier this year.

This article is from St George’s University Hospitals – https://www.stgeorges.nhs.uk/newsitem/st-georges-develops-uk-first-anti-reflux-surgery-service/ 

The Difference Between Chemo and Radiation

When you or a loved one is diagnosed with cancer, it’s normal to have many thoughts running through your head — how bad is it, what does this mean for my future, and what is the treatment actually like?

When referring to treatment, you may hear the words “chemotherapy” or “radiation.” Maybe, you’re told about a combination of both. So, what exactly is the difference between chemo and radiation?

Chemotherapy and Radiation Therapy? What Are the Differences?

What Is Chemotherapy?

Chemotherapy, or chemo, is a process in which drugs are used to treat cancer.

It is a “systemic” treatment — working through the whole body to prevent the spread of the disease. The drug(s) used will vary depending on the type and stage of cancer as well as the patient’s age and health. The goal of chemotherapy is to stop the spread of cancer to other parts of the body.

Chemotherapy is administered by a medical oncology (cancer) health professional, typically a nurse or doctor. Chemo can be delivered as an outpatient procedure, in a hospital, a doctor’s office, or even at home in any of the following ways:

• Injection into muscle, vein, or artery
• Orally
• Injection into the body (such as the abdomen)
• Direct skin application

Chemotherapy side effects

Chemo side effects vary depending on the type and amount of chemotherapy drug used and how the body reacts to it. Because chemotherapy drugs travel through the body, they can also impact healthy cells, leading to a variety of side effects.

Chemo is designed to kill fast-growing cancer cells, but this can sometimes lead to side effects involving the body’s other, healthy fast-growing cells.

• Blood forming cells in the bone marrow (anemia, increased risk of infection, bruising)
• Hair follicles (temporary hair loss)
• Cells in the mouth, digestive and reproductive tract (nausea, loss appetite, constipation, diarrhea)

Some chemo drugs can damage cells in the heart, kidneys, bladder, lungs, and nervous system. Your doctor monitors you closely and may prescribe medicines to protect your body’s normal cells. There are also medicines to help relieve side effects.

What Is Radiation Therapy?

Radiation therapy is the use of high-energy particles or waves to destroy or damage cancer cells.

Radiation is delivered using special equipment that sends high doses of radiation to the cancer cells or tumor. Radiation can also affect healthy cells, however, normal cells can repair themselves, while cancer cells cannot.

Sometimes radiation is used to treat cancer, or it may be used to help you feel better, such as to minimize bone pain, for example. Radiation therapy can take place on its own, but it’s frequently combined with chemotherapy as a comprehensive cancer treatment program.

Radiation therapy differs from chemotherapy — it is used to treat just the tumor, so it affects only the part of the body that has cancer.

Types of radiation therapy

Radiation can be administered in two ways: internally or externally:

External: External beam radiation is delivered from a machine. It is very similar to receiving a chest X-ray. Most people are treated five days a week for one to 10 weeks, depending on the type and location of cancer, their overall health, and other factors. The treatment only takes a few minutes, and is not generally given over the weekend.

You will be asked to lie flat on a treatment table, under the radiation machine. Other parts of your body may be protected with special shields or blocks to prevent the radiation from going to those areas.

External treatments include:

• 3D conformal radiation therapy after the tumor is mapped through imaging, beams of radiation treat the cancerous tumor.
• Intensity-modulated radiation therapy (IMRT) gives the radiation oncologists the ability to more precisely “custom sculpt” the shape of the tumor. This helps deliver the right amount of radiation more accurately, as well as helps to preserve healthy tissue surrounding the tumor.

Internal: Radiation that is placed inside of the body is called internal radiation therapy or brachytherapy. A radioactive source, called an implant, is placed directly to the tumor or near the tumor. This delivers large doses of radiation to directly to the source of your cancer. These implants may look like a wire, pellet, or seeds.

If the implants are left in your body, you may be given special instructions such as to limit your time with and/or avoid children or pregnant women. After a few weeks to a few months, the implants stop giving off radiation, and you can return to normal activities. The implant, however, will remain in your body forever.

Some implants may be removed after a period of hours or days. Most often, they are administered in a hospital private room, and visitors will only be allowed to stay with you for short periods of time.

This article is from UPMC Hillman Cancer Centre – https://share.upmc.com/2016/07/chemotherapy-and-radiation/

Thank you so much to Ray Clark for organising this event for the second time!

Watch the highlights of the Band Appeal 2 on YouTube…

Six acts were together for one-night only in a fundraising event to support The Oesophageal Patients Association!

Performances from …
Daniel Defoe – “Memories from “The Musicals””
Mr. Chris Field – “International Female Impersonator”
Jessica Sharp – “Stunning Female Vocalist”
Jacob Walsh – “The Yorkshire Tenor”
William Knight – “Dazzling Comedy Magician”
Ray Clark – “Voice of the 60’s”

One way to treat gastroesophageal reflux disease (GERD) is through changes in diet and nutrition.  Of course, this approach must be discussed with your doctor before attempting to put into place on your own.  While making changes in your diet may be extremely helpful for some it can also be challenging.   Many are not sure what foods are “safe” to eat and end up wandering aimlessly in the grocery store on their shopping trips.

Millions of people suffer from gastrointestinal (GI) symptoms and distress each year. Diagnoses of leaky gut syndrome, Crohn’s, coeliac disease, and irritable bowel syndrome (IBS) continue to grow. Recently, researchers have acknowledged another digestive disorder: small intestinal bacterial overgrowth, or SIBO. It is more prevalent than previously believed, and occurs in many people suffering from IBS and certain other conditions.1

This article will review what SIBO is, its causes, how it is identified and dietary and supplemental interventions to address the underlying cause.

Skip to Key Takeaways

What is SIBO?

SIBO is an overgrowth of bacteria in the small intestine. These bacteria normally live in the large intestine but have abnormally overgrown in a location not meant for so many bacteria. In a healthy individual, the small intestine, whilst not necessarily completely sterile, should have a very low count of bacteria. SIBO occurs when bacteria colonise the small intestine and then overgrow (this overgrowth is referred to as a dysbiosis).

These bacteria can:

• Ferment dietary sugars and carbohydrates which leads to a build-up of gas. The gas causes abdominal bloating, abdominal pain, constipation, diarrhoea or both (also symptoms of IBS).  Excess gas can also cause belching and flatulence

• Remove B12 from intrinsic factor, which is required for B12 absorption, and therefore SIBO is associated with B12 deficiency

• Cause damage to the small intestine leading to malabsorption and potentially the onset of ‘leaky gut’, a trigger for systemic disease. Undigested food particles, can enter the body and trigger immune activation.  This can cause food intolerances/sensitivities

• Consume food which has not been absorbed due to epithelial lining damage; this continues the overgrowth (a vicious cycle)

• Reduce dietary fat absorption. They are also able to de-conjugate bile acids from fat (bile is essential for emulsifying fat to allow it to be absorbed); this can lead to poor fat absorption and therefore deficiency of essential fatty acids and fat soluble vitamins (i.e. vitamins A, D, E and K) as well as diarrhoea caused by excess fat in the stool

What causes SIBO?

The causes of SIBO seem to be multi-faceted but have been mainly attributed to:

Low stomach acid – hydrochloric acid in the stomach plays many roles, one of which is to sterilise food that has been consumed. If stomach acid is low then excess bacteria can colonise the small intestine.

Poor motility – normal gastrointestinal motility involves a complex, tightly coordinated series of events designed to move material through. It decreases the potential for SIBO by ensuring that food particles and bacteria are moved through the digestive tract, rather than accumulating in the small intestine.

Three patterns of motility are seen – known as peristalsis, segmentation contraction and the migrating motor complex (MMC)

• Peristalsis begins in the oesophagus when a bolus of food is swallowed. It is a series of wave-like muscle contractions that propels foodstuffs through the oesophagus and intestines
• Segmentation contraction is a type of intestinal motility which occurs in the small and large intestine, predominantly in the former
• During periods of fasting, a migrating motor complex (MMC) occurs approximately every 90-120 minutes to sweep residual debris through the GI tract.1 The migrating motor complex (MMC) is a pattern of gut contraction that creates movement through the gut when it is empty. Regulation of the MMC is complex, requiring the release of many hormones and neurotransmitters, as well as the activity of the enteric and autonomic nervous systems.2 This contraction moves through the stomach and small intestine, towards the ileocaecal valve. These waves occur in cycles, playing a housekeeping role, clearing the small intestine of remnants of food and bacteria left behind during peristalsis and segmentation contraction. A small amount of bile and enzymes are released with each MMC and these secretions may also help clean out the small intestine of bacteria build-up. It is this ’sweeping’ of the small intestine that is responsible for the rumbling felt or heard between meals

In a normal MMC cycle, there are four phases. Phase I is a quiescent period with virtually no contractions. Phase II consists of intermittent, irregular low-amplitude contractions. Phase III consists of short bursts of regular high-amplitude contractions. Phase IV represents a short transition period back to the quiescence of phase I.3

If there is dysfunction within any of these movement patterns, gut motility may be decreased, leading to constipation, changes in the gut microbiome, pain, and other digestive symptoms. Particularly, a decrease in phase III activity of the MMC, the most active phase of its four phases, has been shown to be absent in cases of SIBO as well as IBS.4 One of the main contributors to the development of SIBO is small intestine dysmotility.5 Several studies have demonstrated that abnormalities in the MMC may predispose to the development of SIBO.6,7,8

In this case, a prokinetic agent may be useful. The term prokinetic means to promote movement and, in the context of the gastrointestinal tract, was introduced to refer to a class of drugs that promote gastrointestinal motility and, thereby, transit. This stimulatory effect is considered clinically relevant to the management of disorders characterised by impaired motility.  In addition to drugs, there are some natural nutraceuticals with prokinetic effects such as 5-HTP, ginger and triphala.

If motility is poor, which is consistent with constipation, the bacteria present has an opportunity to migrate from the colon to the small intestine.

Other causal factors associated with SIBO are:

• Low pancreatic (digestive) enzymes
• Poor immune function
• Previous bacterial infections e.g. Campylobacter

It is important to address these underlying causes but doing this alone will not eradicate SIBO, this is discussed in more detail later.

How is SIBO identified?

Symptoms that are associated with SIBO include:

• Gas, bloating and flatulence
• Diarrhoea
• Abdominal cramping
• Fat in the stool (stools may have a pale and oily appearance and often float)
• Intolerance to lactose (sugar found in milk)
• B12 deficiency (megaloblastic anaemia)

If these signs and symptoms are seen (particularly in combination) SIBO can be suspected. However there are simple breath tests available to identify the production of hydrogen or methane, which are produced through bacterial fermentation in the small intestine.

Dietary and Supplementary interventions for SIBO

There are dietary and supplement interventions that can specifically support individuals with SIBO, which are outlined below. It can also be beneficial to follow a 5R programme in order to fully rebalance and repair the digestive system, this programme is discussed in our Cytoplan blog: Nutritional support for Irritable Bowel Syndrome.

Avoid FODMAPs

FODMAPs are dietary sugars and carbohydrates which are easily fermented by the bacteria and can exacerbate symptoms of gas, bloating and pain. Therefore it is often very useful to remove them from the diet for a limited period of time.

FODMAPs stand for:

Fermentable

Oligosaccharides (e.g. fructans found in wheat, garlic, onion and chicory etc. and galactans found in legumes including beans, peas and lentils)

Disaccharides (e.g. lactose found in milk products)

Monosaccharides (e.g. fructose found in fruits, honey, high fructose corn syrup etc.)

And

Polyols (found in sweeteners containing isomalt, mannitol, sorbitol, xylitol plus stone fruits such as avocado, apricots, cherries, nectarines, peaches and plums)

After excluding high FODMAP foods for a month, foods from each FODMAP group should be reintroduced, one at a time (e.g. foods containing fructose, then foods containing lactose etc.).

During the reintroduction, symptoms should be monitored and if a FODMAP group of foods causes problems then continue to eliminate this group. It should be noted that avoiding FODMAPs will not remove SIBO but help modulate the symptoms.

Please note that a low FODMAP diet involves initially restricting a considerable number of foods which some may find very difficult; however it is not intended to be a long-term diet and because of the restrictive nature and complexity it is best followed with the guidance of a practitioner.

Remove dysbiotic bacteria from the small intestine

Primarily, the main intervention for SIBO needs to be the removal of bacteria, as addressing underlying causes and avoiding foods which are exacerbating symptoms will not be enough.

Natural antimicrobials can be useful for removing bacteria from the small intestine. These include:

Caprylic acid – a natural dietary fatty acid which assists in the maintenance of normal intestinal micro-flora and can help inhibit the growth of opportunistic fungi such as Candida albicans. Coconut oil is a good source.

Garlic – long standing use as an anti-microbial.

Oregano extract – broad spectrum anti-microbial activity.

Grapefruit seed extract – research shows evidence for anti-bacterial activity against gram-positive and gram-negative bacteria.

Green tea extract – anti-bacterial and anti-fungal activity.

It is sometimes advisable to take a live bacteria supplement along with the anti-microbial (although take at least two hours apart from each other) to help ensure a healthy balance of gut flora in the large intestine.

Address the underlying cause

Low stomach acid

If stomach acid is low this needs to be addressed as there will be a risk of SIBO returning following anti-microbial use if stomach acid insufficiency persists. Symptoms associated with low stomach acid are:

• Poor appetite in morning
• Undigested food in stool
• Bloating and /or pain shortly after eating (30 minutes)
• Heartburn and reflux
• Suspected malabsorption or nutrient deficiencies

It is also possible to test hydrochloric acid levels by consuming a ½  teaspoon of bicarbonate of soda dissolved in a small glass of water on an empty stomach (on rising in the morning is a good time), then timing how long it takes to belch. If it takes longer than 5 minutes (it should happen within 2-3 minutes) this indicates that levels of hydrochloric acid maybe low.

You can support stomach acid levels by:

• Supplementing with betaine hydrochloride just prior to meals or 1 teaspoon of apple cider vinegar in a small amount of water
• Ensuring adequate zinc levels (zinc is important for production of stomach acid)
• Avoiding drinking large quantities of water 30 minutes before and during a meal, as this can dilute stomach acid

Poor motility

If motility is poor, then there will be likely be constipation as there is limited movement of the bowel.  Methane-dominant SIBO is almost always associated with constipation.

Gut motility can be supported by:

• Drinking 1.5 to 2 litres of water and herbal teas per day
• Consuming soluble and insoluble fibre from vegetables, fruits and moderate amounts of wholegrains. Ground flaxseed (linseeds) can be useful
• Moderate exercise and physical activity – walking is ideal
• Vagal nerve exercises – stimulate the vagus nerve by singing loudly and gargling every day (vigorous gargling several times a day if possible)
• Supplementing with
  –    a live bacteria supplement (although some people prefer to wait until symptoms have improved before adding in probiotics)
  –   a magnesium supplement (magnesium is involved in muscle relaxation)
  –   a 5-HTP supplement – which has prokinetic action in the small intestine
  –   Psyllium fibre, slippery elm and

Low pancreatic (digestive) enzymes

If levels of digestive enzymes are low, larger undigested food molecules will be more available for fermentation by bacteria in the small intestine. There are tests available to determine digestive enzyme levels, but in cases of SIBO it is likely that digestive enzyme function is already somewhat impaired and therefore supporting pancreatic enzymes as well as bile production, in the short term, may help with symptom relief.

Pancreatic and digestive function can be supported by:

• Taking a digestive enzyme supplement with meals
• Consuming bitter foods (lemon, rocket, chicory, watercress) which stimulate bile secretion
• Obtaining phospholipids from the diet or as a supplement to aid fat emulsification (e.g. lecithin)

Support for the gut barrier lining

An important part of any intervention to address SIBO is to consider support for the digestive barrier lining – to reduce intestinal permeability or leaky gut. Overall nutritional status should be considered along with specific nutrients such as vitamins A and D and zinc; curcumin, Aloe vera, lactoferrin and L-glutamine are other examples of nutrients used in gut healing programmes. If barrier integrity is not restored then you may not see a full resolution of symptoms.

Conclusion

There is an increased recognition of SIBO as a contributing factor in IBS, functional abdominal pain and a host of other chronic conditions.  Although SIBO can be challenging to work with and tends to be recurrent, there are many options that can provide significant relief as detailed above.

This article is from Cytoplan Blog – https://blog.cytoplan.co.uk/small-intestine-bacterial-overgrowth-sibo-causes-symptoms-nutritional-interventions/

This meeting will be held at the Conference Centre, Holiday Inn Hotel, Egerton Road, Guildford, GU2 7XZ on Thursday 29th August 2019 at 18:30.

The Speaker will be Alistair Ironside from St Barts Cancer Researcher.

More information on the link below…

https://www.opa.org.uk/guildford-2.html

You can order your OPA Christmas Cards on our OPA Shop. Or by downloading and posting the order form to us or email enquiries@opa.org.uk

Here are this year’s wonderful seasonal designs to choose from… “Bluetit”, “Snowfall, Hockley Woods, Essex”, “Winter Robin”, “Snowfall, Southend-on-sea, Essex”, “Winter Scene, Leigh-on-Sea, Essex”, “Snowfall, Thorpe Bay, Essex”, all from paintings by Christine Muckley.

Our new offices are located in Hockley Heath (full address below).

6 & 7
Umberslade Business Centre
Pound House Lane
Hockley Heath
Solihull
B94 5DF